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Thorac Cardiovasc Surg 2023; 71(03): 197-205
DOI: 10.1055/s-0041-1740558
Original Basic Science

Dexmedetomidine Can Reduce the Level of Oxidative Stress and Serum miR-10a in Patients with Lung Cancer after Surgery

Authors

  • Yan Zhou

    1   Department of Anesthesiology, The First People's Hospital of Jinan, Jinan, Shandong Province, China

  • Xia Dong

    2   Department of Anesthesiology, Shizhong District People's Hospital of Jinan, Jinan, Shandong Province, China

  • Lei Zhang

    3   Department of Operating Room, The First People's Hospital of Jinan, Jinan, Shandong Province, China

Funding Not applicable.
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Abstract

Objective Lung cancer is a primary cause of cancer death. This study assessed the action of dexmedetomidine (DEX) on oxidative stress (OS) and microRNA 10a (miR-10a) in patients with lung cancer.

Methods Patients were given 1 µg/kg DEX before anesthesia and control patients were given saline. The duration of intraoperative one-lung ventilation (OLV) and fluid intake were determined, and mean arterial pressure, heart rate and bispectral index were observed at the time of before anesthesia (T0), immediately after endotracheal intubation (T1), 1 hour after OLV (T2), and 10 minutes before the end of surgery (T3). The expressions and correlations of miR-10a, inflammation and OS levels in the serum were analyzed. The effects of DEX intervention and miR-10a level on pulmonary complications were analyzed.

Results Patients with DEX intervention had lower levels of inflammation and OS during perioperative period than the controls. DEX intervention reduced miR-10a levels in patients during perioperative period. miR-10a in serum of patients with DEX intervention after surgery was positively-correlated with the concentrations of malondialdehyde, and inflammatory factors, while negatively-correlated with superoxide dismutase. The total incidence of postoperative pulmonary complications after DEX intervention was lowered. Patients with high miR-10a expression had a higher cumulative incidence of pulmonary complications than those with low miR-10a expression.

Conclusion DEX can reduce postoperative OS and plasma miR-10a level in patients with lung cancer, and high expression of miR-10a predicts a high incidence of postoperative pulmonary complications.

Keywords

dexmedetomidine - lung cancer - miR-10a - inflammatory cytokines - oxidative stress - pulmonary complications - Pearson coefficients

Ethics Approval

This study was ratified by the Academic Ethics Committee of The First People's Hospital of Jinan. All patients in this study were fully informed of the purpose of this study and signed the informed consent before sampling.


Availability of Data and Materials

All the data generated or analyzed during this study are included in this published article.


Authors' Contributions

YZ contributed to the study concepts, study design, and guarantor of integrity of the entire study; XD contributed to the literature research; YZ, LZ contributed to the experimental studies and data acquisition; YZ, XD contributed to the manuscript preparation and LZ contributed to the manuscript editing and review. All authors read and approved the final manuscript.


Competing Interests

The authors declare that they have no competing interests.


Supplementary Material



Publication History

Received: 22 July 2021

Accepted: 19 October 2021

Article published online:
18 January 2022

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